Effect of azithromycin on gingival overgrowth induced by cyclosporine A + nifedipine combination therapy: A morphometric analysis in rats

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Therapy for nifedipine-induced gingival overgrowth by saireito in rats

OBJECTIVE A calcium antagonist, nifedipine, causes gingival overgrowth as a side effect. It has been confirmed that the Japanese traditional medicine, Saireito, inhibits the nifedipine-induced proliferation of gingival fibroblasts in vitro. We performed an in vivo experiment to determine whether Saireito has a therapeutic use in the treatment of nifedipine-induced gingival overgrowth. METHODS...

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Cyclosporine-A Induced Gingival Overgrowth

Background. The link between the gingival overgrowth and cyclosporine pharmacokinetical variables, especially cyclosporine doses which appear to act as stimulator of the gingival proliferative changes, presents a field of interest of large number of researches. The existence of undefined association and/or interaction between the cyclosporine and periodontal variables, could be responsible for ...

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Treatment of cyclosporine-induced gingival overgrowth with azithromycin-containing toothpaste.

OBJECTIVES Gingival overgrowth is a complication of cyclosporine therapy following organ transplantation. Oral azithromycin is frequently used to treat this complication. This study examined the efficacy of local azithromycin, in the form of toothpaste, against cyclosporine-induced gingival overgrowth. MATERIALS AND METHODS Twenty stable renal transplanted patients (10 men and 10 women) with ...

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15 صفحه اول

The effect of cyclosporine with and without nifedipine on gingival overgrowth in renal transplant patients.

PURPOSE This investigation was performed to evaluate the effect of cyclosporine alone and in combination with nifedipine on gingival overgrowth. METHODS One hundred and nineteen patients who had undergone renal transplantation at least 12 months previously were selected for the study. The patients were divided into 2 groups according to whether they had received cyclosporine alone (group 1, n...

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ژورنال

عنوان ژورنال: Journal of Indian Society of Periodontology

سال: 2016

ISSN: 0972-124X

DOI: 10.4103/0972-124x.194271